• Burns: Used for partial-thickness burns to promote healing and reduce pain.
    • Venous Stasis Ulcers: Applied to chronic venous stasis ulcers to accelerate healing.
    • Pressure Ulcers: Used to treat bedsores that do not respond well to conventional treatments.

    • Tendon and Ligament Injuries: Applied to injuries like tendinitis and ligament sprains to enhance recovery and reduce inflammation.
    • Plantar Fasciitis: Injected or applied to reduce pain and inflammation associated with plantar fasciitis.

    • Persistent Epithelial Defects: Used in patients with non-healing corneal epithelial defects that do not respond to standard treatments.
    • Severe Dry Eye Syndrome: Applied in severe cases of dry eye to promote healing of the ocular surface and reduce symptoms.

    • Plastic and Cosmetic Surgery: Used as a biological dressing in various reconstructive procedures to improve healing and reduce scarring.
    • Breast Reconstruction: Applied in breast reconstruction surgeries to support tissue regeneration and reduce adhesions.

    • Vaginal Reconstruction: Used in surgical procedures for vaginal reconstruction to support tissue healing and reduce scarring.
    • Asherman's Syndrome: Applied to the uterine lining to reduce intrauterine adhesions and improve endometrial health.

    • Bladder Augmentation: Used in procedures to augment the bladder, aiding in tissue regeneration and reducing complications.

• Joint Injuries, Tendon and Ligament Injuries, Arthritis: These applications are largely in the research phase, with some being used off-label by practitioners based on preliminary evidence and clinical experience.

• Chronic Ulcers, Surgical Wounds: These uses are typically in the research phase or used off-label. Some wound care products derived from umbilical cord tissue may be FDA-cleared as wound dressings, but their specific application to chronic ulcers and surgical wounds as described is not FDA-approved.

• Nerve Injuries, Neurodegenerative Diseases: These are primarily in the research phase with ongoing clinical trials exploring their efficacy and safety.

• Heart Repair, Peripheral Artery Disease: These applications are in the experimental phase with active research and clinical trials assessing their potential benefits.

• Corneal Defects, Dry Eye Syndrome: These uses are mostly in the research phase or used off-label based on promising results from preliminary studies and clinical trials.

• Skin Grafts, Burn Treatment: Some applications are in the research phase, while others might be used off-label. Specific products derived from umbilical cord tissue may be used in wound care, but not necessarily FDA-approved for these detailed applications.

• Pelvic Floor Disorders, Endometrial Regeneration: These applications are largely in the research phase, with ongoing studies exploring their potential benefits.

Leukemias: a cancers of the blood immune system, where the cells are called leukocytes or white cells.
     • Acute Biphenotypic Leukemia
     • Acute Lymphoblastic Leukemia (ALL)
     • Acute Myelogenous Leukemia (AML)
     • Acute Undifferentiated Leukemia
     • Chronic Lymphocytic Leukemia (CLL)
     • Chronic Myelogenous Leukemia (CML)
     • Juvenile Chronic Myelogenous Leukemia (JCML)
     • Juvenile Myelomonocytic Leukemia (JMML)
Myelodysplastic Syndromes: also called pre-leukemia.
     • Refractory Anemia
     • Refractory Anemia with Ringed Sideroblasts
     • Refractory Anemia with Excess Blasts
     • Refractory Anemia with Excess Blasts in Transformation
     • Chronic Myelomonocytic Leukemia (CMML)
Lymphomas: a cancer of the blood immune system, where the cells are called leukocytes or white cells.
     • Hodgkin’s Lymphoma
     • Non-Hodgkin’s Lymphoma (Burkitt’s Lymphoma)
Solid Tumors: not originating in the blood or immune system.
     • Neuroblastoma
     • Retinoblastoma
     • Medulloblastoma

Anemias: deficiencies or malformations of red cells.
     • Aplastic Anemia
     • Congenital Dyserythropoietic Anemia
     • Fanconi Anemia
     • Paroxysmal Nocturnal Hemoglobinuria (PNH)
Inherited Red Cell (Erythrocyte) Abnormalities: red cells contain hemoglobin and carry oxygen to the body.
     • Beta Thalassemia Major (also known as Cooley’s Anemia)
     • Diamond-Blackfan Anemia
     • Pure Red Cell Aplasia
     • Refractory Anemia with Excess Blasts in Transformation
     • Sickle Cell Disease
Inherited Platelet Anomalies: platelets are blood cells needed for clotting.
     • Amegakaryocytosis / Congenital Thrombocytopenia
     • Glanzmann Thrombasthenia
Inherited Immune System Disorders | Severe Combined Immunodeficiency
     • SCID with Adenosine Deaminase Deficiency(ADA-SCID)
     • SCID which is X-linked
     • SCID with absence of T & B Cells
     • SCID with absence of T Cells, Normal B Cells
     • Omenn Syndrome
Inherited Immune System Disorders | Neutropenias
     • Infantile Genetic Agranulocytosis (Kostmann Syndrome)
     • Myelokathexis
Inherited Immune System Disorders | Other
     • Ataxia-Telangiectasia
     • Bare Lymphocyte Syndrome
     • Common Variable Immunodeficiency
     • DiGeorge Syndrome
     • Leukocyte Adhesion Deficiency
     • Lymphoproliferative Disorders
     • Lymphoproliferative Disorder, X-linked (also known as Epstein-Barr Virus Susceptibility)
     • Wiskott-Aldrich Syndrome
Myeloproliferative Disorders
     • Acute Myelofibrosis
     • Agnogenic Myeloid Metaplasia (Myelofibrosis)
     • Polycythemia Vera
     • Essential Thrombocythemia
Phagocyte Disorders
     • Chediak-Higashi Syndrome
     • Chronic Granulomatous Disease
     • Neutrophil Actin Deficiency
     • Reticular Dysgenesis
Cancers in the Bone Marrow
    • Multiple Myeloma
    • Primary Plasma Cell Leukemia (PCL)
    • Secondary Plasma Cell Leukemia
    • Waldenstrom’s Macroglobulinemia

Inherited Disorders: immune system and other organs.
    • Cartilage-Hair Hypoplasia
    • Gunther’s Disease (Erythropoietic Porphyria)
    • Hermansky-Pudlak Syndrome
    • Pearson’s Syndrome
    • Shwachman-Diamond Syndrome
    • Systemic Mastocytosis

Mucopolysaccharidosis (MPS) Storage Diseases
    • Hunter Syndrome (MPS-II)
    • Hurler Syndrome (MPS-IH)
    • Maroteaux-Lamy Syndrome (MPS-VI)
    • Morquio Syndrome (MPS-IV)
    • Sanfilippo Syndrome (MPS-III)
    • Scheie Syndrome (MPS-IS)
Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
    • Mucolipidosis II (I-cell Disease)
Leukodystrophy Disorders
    • Adrenoleukodystrophy (ALD) / Adrenomyeloneuropathy (AMN)
    • Krabbe Disease (Globoid Cell Leukodystrophy)
    • Metachromatic Leukodystrophy
    • Pelizaeus-Merzbacher Disease
Lysomal Storage Disorders
    • Niemann-Pick Disease
    • Sandhoff Disease
    • Wolman Disease
Inherited Disorders-Other
    • Lesch-Nyhan Syndrome
    • Osteopetrosis